כולסטרול: הטוב הרע והמכוערכולסטרול זה טוב?כולסטרול זה רע?מי צריך אותו בכלל?האם אפשר בלעדיו?
לצפיה בכל תוכן המצגת :
לחצו כאן:
. . . (... ) ( .( ) . : )
(
)
9-
!!! 3
6
= .
: .1 .70%30% .2
. D . .......
. .( : .(LDL) . (HDL) )
.
-
. -
(low density lipoprotein) LDL ." " (high density lipoprotein) HDL ." "
" . .
" "
" "
"± .
. .
. . . .
220 1% !20% .80 45 1% ! : . .2%
: :(total cholesterol ) 180 - 200:(LDL cholesterol) 130 :(HDL cholesterol)
"
" .150 -
.55 3-4% 4- 1 50 .(4:1 = 200:50) 200 .3:1
Familial hypercholesterolemia is a rare genetic disorder characterized by very high LDL cholesterol and early cardiovascular disease running in families .
A mutation in either the LDL receptor or the ApoB100 protein. There is one known ApoB defect (R3500Q) and a multitude of LDL receptor defects the frequency of which is different for each population .
-
.
1984
HMG-CoA-R.
. . (1987- ) Merck . . "
"
-atorvastatin . " 80 - " " 80 - " lescol- -Fluvastatin . 80 - " lovalip mevacor- . " zocor lipex simovil- . " 80 - " 0.8 - " 0.4 lipogis baycol- . " 20 lipidal pravachol lipostat- . " 40 - "
.
torvast-
-
. CDC . "
.
50%
.
. . " . . . 5% -( ) ( )
. 2
.1
.2 .3
."
.4
.
. ) . . "
.1
3
(
3
.2
.HDL ± ( .
" /
)
. . / 10) 1/2-1
.3 .4 .5
.HDL ±
. . .E . 3 . ± C / -
.1 .2 .3 .4 .5
:
36
-
-
-